On my M1 Mac mini, KensingtonWorks software somehow disables double-clicking on my Kensington Slimblade trackball. I can assign another button to perform a double-click, but it is hard not to double-click anyway, after doing so since the late 1980s.
I found a third party mouse utility called SteerMouse that does a much better job than KensingtonWorks, and offers a lot more options. I’m not sure I want to spend $20 on it, but I do like all my mouse buttons to do something.