I have been using AutoHotKey for many years, and I never thought until today to map Windows+Q to quit the active app and close the active window. That creates something very similar to Mac’s Command+Q shortcut to Windows.

The default Windows keyboard shortcut for quitting an app is Alt+F4, which is a two hand operation for me. Note that in AutoHotKey, you don’t even need to send that key command; you can use the WinClose function instead:

WinClose, A  

One of the best things Apple has ever done with their support of keyboard shortcuts was to pretend that function keys (F1 through F12) don’t exist.